Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.
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Diazepam emulsified injection should be prepared for single patient use only. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Use is not recommended as a hypnotic due to the long half-life of diazepam, the availability of safer sleep agents, and the increased sensitivity to benzodiazepines informatipn.
Diazepam use during breast-feeding is not recommended. Fosphenytoin should be used cautiously with clonazepam and diazepam, as decreased clonazepam or diazepam serum concentrations may be seen. If direct IV access is not feasible, inject slowly via infusion tubing as close as possible to the vein insertion.
Amphetamines may decrease the seizure threshold and may increase the risk of seizures. Dose reduction may be necessary. Moderate Amoxapine may enhance the response to the effects of benzodiazepines and other CNS depressants.
The infants’ mean serum concentration decrease from days 4 to 6 may be due to decreases in the amount of milk consumed or the onset of elimination mechanisms. Lofexidine can potentiate the effects of CNS depressants such as benzodiazepines. Advise patients who become pregnant or intend to become pregnant while taking diazepam to discuss the possibility of discontinuing the drug with their physician.
Put person on their side where they can not fall. However, as a single mg intravenous dose, fosaprepitant only weakly inhibits CYP3A4 for a duration of 2 days; there is no evidence of CYP3A4 induction. Not recommended as prezcribing first-line agent due to sodium benzoate and benzoic acid in the injection see Precautions and How Supplied.
Grapefruit juice has been shown to increase diazepam peak serum concentrations Cmax and exposure AUC by 1. Diazepam is associated with teratogenic effects in animals.
Patient counseling is important, as cisapride alone does not cause drowsiness or affect psychomotor function. Moderate Drugs that can cause CNS depression, if used concomitantly with iloperidone, may increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, and dizziness.
Moderate Concomitant administration of benzodiazepines with zolpidem can potentiate the CNS effects e. It is recommended that rectal diazepam be used to treat no more than five episodes per month and no more than one episode every five days. Ten of 11 patients were discharged inflrmation from the hospital. Diazepam is administered orally, rectally, and parenterally. Inject deeply into a large muscle mass. At least one case of sudden death was reported following intravenous administration of lorazepam to a patient receiving clozapine.
Lower doses are recommended in patients with chronic respiratory insufficiency. Educate patients about the risks and symptoms of respiratory depression and sedation. In addition, the risk of next-day psychomotor impairment is increased during co-administration of eszopiclone and other CNS depressants, which may decrease the ability to perform tasks requiring full mental alertness such as driving.
Moderate Dalfopristin; quinupristin is a major inhibitor of cytochrome P 3A4 and may decrease the elimination of drugs metabolized by this enzyme including diazepam. Use caution when administering these diastaat concomitantly.
Flumazenil does not affect the pharmacokinetics of the benzodiazepines. The magnitude of this interaction may be pdescribing in patients who are also receiving cyclosporine. Minor Caffeine, an active constituent of guarana, is a CNS stimulant associated with heightened attentiveness and insomnia, and is used to treat or prevent drowsiness or fatigue; patients taking benzodiazepines for insomnia should not use guarana-containing products prior to going to bed as these products may antagonize the sedative effects of the benzodiazepine or zolpidem.
Ciprofloxacin has been shown to decrease the clearance and increase the half-life of diazepam. Large quantities of benzodiazepines should not be prescribed for patients with known suicidal ideation or a history of suicide attempt.
Moderate Use caution if coadministration of telotristat ethyl and diazepam is necessary, as the systemic exposure of diazepam may be decreased resulting in reduced efficacy.
Limit the use of ifnormation pain medications with benzodiazepines to only patients for whom alternative treatment options are inadequate. Continue monitoring during concomitant treatment and decrease the digoxin dose as necessary.
If the extended-release tapentadol tablets are used concurrently with a benzodiazepine, use an initial tapentadol dose of 50 mg PO every 12 hours. Your Name Your name is required. Moderate Benzodiazepines or other CNS depressants should be combined cautiously with maprotiline because they could cause additive depressant effects and possible respiratory depression or hypotension.
Due to its long half-life and the availability of safer alternatives, diazepam is not recommended for the treatment of insomnia in the elderly. Besides ethanol, clinicians should prescriibing other anxiolytics, sedatives, and hypnotics cautiously with olanzapine.
This can result in substantial increases in the half-life of diazepam, and the psychomotor and physiological response may be altered. Caution should be used when asenapine is given in combination with other centrally-acting medications including anxiolytics, sedatives, and hypnotics including barbituratesbuprenorphine, buprenorphine; naloxone, butorphanol, dronabinol, THC, nabilone, nalbuphine, opiate agonists, pentazocine, acetaminophen; pentazocine, aspirin, ASA; pentazocine, and informmation naloxone.
Flumazenil does not reverse the actions of barbiturates, opiate agonists, or tricyclic antidepressants. Atropine; Hyoscyamine; Phenobarbital; Scopolamine: Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Adults, Adolescents and Children 12 years of age.
Abrupt discontinuation of diazepam after prolonged use should be avoided.