What abrin is. Abrin is a natural poison that is found in the seeds of a plant called the rosary pea or jequirity pea. These seeds are red with a black spot covering. Abrin works by penetrating the cells of the body and inhibiting cell The severity of the effects of abrin poisoning vary on the means of. At the cellular level, abrin inhibits protein synthesis, thereby causing cell death. Many of the features observed in abrin poisoning can be.
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Abrin has some potential medical uses, such as in treatment to kill cancer cells. Many of the features observed in abrin poisoning can be explained by abrin-induced endothelial cell damage, which causes an increase in capillary permeability with consequent fluid and protein leakage and tissue piosoning the so-called vascular leak syndrome.
Excess fluid in the lungs can be diagnosed by x-ray or by listening to the chest with a stethoscope. Case records of patients admitted to medicine wards during 7 years were included in the study.
Abrin in the powder or mist form can cause redness and pain in the eyes i. Intact A precatorius often pass through gastrointestinal GI tract without harm, whereas ingestion of crushed seeds will be of great toxicity to human body. Therefore, her estimated dose of ingested abrin was Considering the severity of abrin poisoning and hemodynamic instability, traditional hemodialysis was not initially considered. Quickly take off clothing that may have abrin on it.
Published by Wolters Kluwer – Medknow. How you can get more information about abrin You can contact one of the following: Other signs or symptoms may include hallucinations, seizures, and blood in the urine.
Eur J Biochem ; Following ingestion of the seeds, the girl developed multiple symptoms of nausea and vomiting. J Assoc Physicians India ; Archived from the original on She was given clear liquids and advanced to a regular diet when emesis ceased. Effects of abrin poisoning depend on whether abrin was breathed in, swallowed, or injected. If you wear contacts, put them poiaoning the plastic bag, too.
Phosphine Phosphorus, elemental, white or yellow Case Definition: ThomasJohn J. Survival after an intentional ingestion of crushed abrus seeds. Abrin, Mechanisms of toxicity, Poisoning, Ribosome-inactivating proteins. April 4, Page last updated: Details of patients who died from Abrus precatorius poisoning Click here to zbrin.
Do not put the contacts back in your eyes even if they are not disposable contacts. Ribosome-inactivation tests can accurately determine if clinical samples test positive for the toxin abrin [ 38 ]; however, the test cannot provide a measure of the concentration of abrin in the body which may help in patient management. Because no antidote exists for abrin, the most important factor is avoiding abrin exposure in the first place. The combination of CRRT and HP is an efficient measure in the treatment of abrin poisoning for which there is no specific antidote.
If an exposure to abrin by inhalation is not fatal, the airway can become sensitized or irritated. Oxygen therapyairway managementassisted ventilationmonitoringIV fluid administrationand electrolyte replacement are also important components of treatment.
If your eyes are burning or your vision is blurred, rinse your eyes with qbrin water for 10 to 15 minutes. Death from abrin poisoning could take place within 36 to 72 hours of exposure, depending on the route of exposure inhalation, ingestion, or injection and the dose received.
Abrin is a highly toxic protein obtained from the seeds of A precatoriuswith an estimated human fatal dose of 0. J Clin Toxicol ;